For analytical HPLC, CHROMATOREX-SMB offer a

selection between 3 and 5 ｵm. The 5 ｵm particles are

particularly recommended for method development

start-up to help the optimization of the method.

For preparative HPLC, either at pilot stage or for high

value purification processes, the 10 ｵm particles are

preferred for those applications requiring higher

resolution, while the 15 ｵm particles offer a good

compromise between performance and cost.

The larger particle size 20 and 20 / 45 ｵm are well

suited for medium pressure columns.

CHROMATOREX-SMB with pore sizes 7, 10 and 20

nm are recommended for the purification of natural

and synthetic small molecules, lipid soluble organic,

small organic chemical compounds.

Larger pore sizes, 30, 50, 80 or 100 nm are

preferred to optimize the capacity and the yield for

the purification of medium to large peptides and

proteins.

Silica gel quality is critical to achieve optimum

performance when using the Flash chromatography

method.

The particle size distribution and the particle shape

determine the resolution and the speed.

For efficient mass transfer, CHROMATOREX-MB

spherical silica gels have a tight control of particle

size distribution allowing less than 10% particles

upside and downside the defined distribution range.

Two standard particle size distributions are offered.

Surface area, water content and surface pH

determine the capacity of the silica gel.

CHROMATOREX-MB is fully porous silica, and the

rigorous control of the pore volume and pore size

distribution ensures the accessibility for the targeted

molecule to reach the maximum surface area.

CHROMATOREX-MB with pore sizes 7 and 10 nm

and recommended for the purification of natural and

synthetic small molecules, lipid soluble organic,

small organic chemical compounds.

Larger pore sizes, 30 nm are preferred to optimize

the capacity and the yield for the purification of

medium to large peptides and proteins.

CHROMATOREX-GS are particularly well adapted for

the application not requiring a high number of

theoretical plate, such as open column, or low

pressure column, or even batch process.

For efficient mass transfer, CHROMATOREX-GS have

a tight control of particle size distribution allowing less

than 10% particles upside and downside the defined

distribution range.

CHROMATOREX-GS with 6nm pore size and a

surface area of 500 m2/g is recommended for the

purification of natural and synthetic small molecules,

lipid soluble organic, small organic chemical

compounds.

The large capacity of the CHROMATOREX-GS makes

it widely use for crude pre-purification step.

The growing interest in complex synthetic or

recombinant peptides has expanded the need for high

performance bonded phase process chromatography.

The use of bonded phases for injectable biological

products has also created new demands.

The fact that we manufacture the starting gels in very

large batch quantities constitues an important

contribution to the overall reproducibility of these

reversed phase silica.

Moreover, our production capacity for derivatization

per batch contributes also to a high level of

reproducibility.

Each lot is extensively tasted for carbon load and

chromatography retention times, efficiency and peak

symmetry. The quality of the surface coverage is

tasted by the Phenol/Pyridine test to evaluate any

remaining free acid groups on the silica surface.

This is the most versatile and popular reversed phase.

The choice of the pore size must be carefully selected

in relation to the molecular weight of the molecule.

Universal, but less performing than C18, it is the

primary choice for investigation.

Specific reversed phase for medium / polar molecules,

shows a high selectivity for acceptor / donor

compounds.

Extremely performing when bonded in wide pore silica

for bio-chromatography and polar compounds.